Curcumin



Mechanism of Action
Curcumin acts as an anti-oxidant, anti-inflammatory, and anti-cell recycling agent. It interacts with cell survival, division, and death signaling pathways: preventing, ameliorating and eliminating cancer and neuropathic disorders.

Cancer Applications
Tumor growth inhibition of xeno-transplanted human pancreatic, prostate, breast, colon, brain and lymphoma tumors in mice indicate clinical cancer utility.

Neurodegenerative Applications
Passage of all three formulations across the blood brain barrier, and concentration in the hippocampus, brainstem, and striata suggest utility in Parkinson’s disease, Post Traumatic Stress Disorders, Alzheimer’s disease, progressive supranuclear palsy, and diabetic neuropathy.

Diabetes Applications
There are over 200 million type 2 diabetes patients worldwide. Curcumin may have preventative effects against the adverse reactions associated with the use of oral and injectable anti-diabetic drugs.

Drug Induced Cardio Toxic Applications
The liposomal formulation mitigates cardiac potassium channel blockade.


Picture. In vivo efficacy study of four nude mice bearing xenografts of human pancreatic cancer metastatic cancer cell line Pa03C. Tumor sizes in mice treated parenterally with polymer alone, nanocurc®, gemcitabine or nanocurcumin+gemcitabine revealed no discernable tumor at the end of week #3 in the combination-treated mouse (Courtesy of Dr A. Maitra, Johns Hopkins University School of Medicine)